At the hospital, she develops further symptoms of kidney failure and bleeding lung, which requires her to have a lung transplant. After a chance conversation with Hugo, and subsequent questioning of Della, House arrives at the diagnosis of sickle cell trait.
This episode marks the first time Cuddy and House go to work after getting together.
When House announces to his team and Wilson that he is dating Cuddy, Wilson (Robert Sean Leonard) is disbelieving, Chase (Jesse Spencer) is indifferent, Foreman (Omar Epps) is in favor, whereas Taub (Peter Jacobson) is rightly apprehensive about how the relationship will affect the team's working.
Cuddy and House begin give in to each other's decisions to avoid unpleasant confrontations.
When House realizes this, he avoids Cuddy in the workplace, rather than speak to her about it.