Most deaths due to colon cancer are associated with metastatic disease.
A gene that appears to contribute to the potential for metastatic disease, metastasis associated in colon cancer 1 (MACC1), has been isolated.
It is a transcriptional factor that influences the expression of hepatocyte growth factor.
Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases.
During colonoscopy, small polyps may be removed if found.