Progesterone therapy for endometrial hyperplasia and neoplasia induces glandular secretory changes, decidual reaction, and spiral arterioles.
Their causal relationship to tamoxifen therapy is debatable.
Departments of Pathology and Obstetrics-Gynecology and Reproductive Science, The Mount Sinai-NYU Medical Center, New York, New York Hormone therapy is widely used throughout the world by women of all ages for a variety of reasons, ranging from oral contraception and ovulation stimulation for family planning to hormone replacement therapy in menopause, to adjuvant therapy of tumors of the breast and uterus.
The histopathologic changes of the uterus, and particularly of the endometrium, associated with these therapies encompass a variety of morphologic features that are often difficult to interpret.
Departments of Pathology and Obstetrics-Gynecology and Reproductive Science, The Mount Sinai-NYU Medical Center, New York, New York Correspondence: Liane Deligdisch, M.
D., Mount Sinai Medical Center, Department of Pathology, One Gustave Levy Place, New York, NY 10029. The endometrial tissue is a sensitive target for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility.