In a related article on geologic ages (Ages), we presented a chart with the various geologic eras and their ages.
The latest high-tech equipment permits reliable results to be obtained even with microscopic samples.
Radiometric dating is self-checking, because the data (after certain preliminary calculations are made) are fitted to a straight line (an "isochron") by means of standard linear regression methods of statistics.
The slope of the line determines the date, and the closeness of fit is a measure of the statistical reliability of the resulting date.
Technical details on how these dates are calculated are given in Radiometric dating. As with any experimental procedure in any field of science, these measurements are subject to certain "glitches" and "anomalies," as noted in the literature.
Here is one example of an isochron, based on measurements of basaltic meteorites (in this case the resulting date is 4.4 billion years) [Basaltic1981, pg. Skeptics of old-earth geology make great hay of these examples.